Advanced morphological neuroimaging study in lateral temporal lobe epilepsy: A multicentric study

作者：Vasta Roberta; Sarica Alessia; Bisulli Francesca; Di Gennaro Giancarlo; D'Aniello Alfredo; Difrancesco Jacopo C; Canafoglia Laura; Casazza Marina; Franceschetti Silvana; Stipa Carlotta; Tinuper Paolo; Mumoli Laura; Gambardella Antonio; Labate Angelo^*

来源：Epilepsy and Behavior, 2017, 74: 69-72.

DOI：10.1016/j.yebeh.2017.06.017

• Lateral temporal lobe epilepsy
• Imaging alterations
• Multimodal approach

Lateral temporal lobe epilepsy (lTLE) is a rare condition characterized by auditory auras or receptive aphasia, negative MRI, and relatively benign evolution. With the low number of cases in the world, our objective was to analyze a cohort of sporadic caseswith lTLE (slTLE), in order to investigate possible cerebralmorphological alterations. Forty patientswith lTLE (34.93 +/- 12.08 years of age) and 38 healthy controls (CTRL, 34.55 +/- 9.08 years of age) were enrolled from four tertiary Italian epilepsy centers, which provided brain MRI T1-weighted images following a standard protocol for patientswith epilepsy. Weperformed group comparison by following different approaches: voxel-based morphometry (VBM, SPM8), cortical thickness (CT), and local gyrification index (lGI) (FreeSurfer 5.3). At amore conservative threshold (p < 0.05, FWEcorrection), no significant differences between groups survived, neither in VBM nor CT/lGI. Multicenter studies have more power than smaller studies in conducting sophisticated evaluations of rare diseases, and further investigations are required to develop a full picture of this rare phenotype.

• 出版日期2017-9