Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies

作者：Lesch Klaus Peter^*; Timmesfeld Nina; Renner Tobias J; Halperin Rebecca; Roeser Christoph; Nguyen T Trang; Craig David W; Romanos Jasmin; Heine Monika; Meyer Jobst; Freitag Christine; Warnke Andreas; Romanos Marcel; Schaefer Helmut; Walitza Susanne; Reif Andreas; Stephan Dietrich A; Jacob Christian

来源：Journal of Neural Transmission, 2008, 115(11): 1573-1585.

DOI：10.1007/s00702-008-0119-3

• Attention-deficit/hyperactivity disorder
• Adult ADHD
• Drug abuse
• Substance use disorder
• Genome-wide association
• GWA
• Pooled DNA
• 500K SNP array
• 50K SNP array
• Linkage
• Candidate genes
• Cell adhesion
• Signal transduction
• Synaptic plasticity

A genome-wide association (GWA) study with pooled DNA in adult attention-deficit/hyperactivity disorder (ADHD) employing similar to 500K SNP markers identifies novel risk genes and reveals remarkable overlap with findings from recent GWA scans in substance use disorders. Comparison with results from our previously reported high-resolution linkage scan in extended pedigrees confirms several chromosomal loci, including 16q23.1-24.3 which also reached genome-wide significance in a recent meta-analysis of seven linkage studies (Zhou et al. in Am J Med Genet Part B, 2008). The findings provide additional support for a common effect of genes coding for cell adhesion molecules (e.g., CDH13, ASTN2) and regulators of synaptic plasticity (e.g., CTNNA2, KALRN) despite the complex multifactorial etiologies of adult ADHD and addiction vulnerability.

• 出版日期2008-11
• 单位河北医科大学