Association of X-ray cross-complementing group 3 Thr241Met gene polymorphism with osteosarcoma risk and its development and prognosis

作者：Wang, Yanwei; Wang, Guantiang; Dong, Zhiyong^*

来源：Journal of Cancer Research and Therapeutics, 2018, 14(7): S1178-S1182.

DOI：10.4103/0973-1482.199435

• Gene polymorphism
• meta-analysis
• osteosarcoma
• Thr241Met
• X-ray cross-complementing group 3

Aim of Study: The relationship between X-ray cross-complementing group 3 (XRCC3) Thr241Met gene polymorphism and osteosarcoma risk and its development and prognosis is still debated. This meta-analysis was performed to assess these associations. Materials and Methods: The association studies were identified from PubMed, and eligible reports were included and calculated using meta-analysis method. Results: Interestingly, all the included studies were from Asian population. The meta-analysis indicated that XRCC3 Thr241Met gene polymorphism was associated with osteosarcoma risk (T allele: Odds ratio [OR] =1.57, 95% confidence interval [CI]: 1.25u1.98, P = 0.0001; TT genotype: OR = 2.23, 95% CI: 1.40-3.57, P = 0.0008; CC genotype: OR = 0.69, 95% CI: 0.54u0.87, P = 0.002). However, XRCC3 Thr241Met CC genotype was not associated with Enneking stage, tumor location, and tumor metastasis. Conclusion: XRCC3 Thr241Met gene polymorphism was associated with osteosarcoma risk, but XRCC3 Thr241Met CC genotype was not associated with Enneking stage, tumor location, and tumor metastasis.

• 出版日期2018-12
• 单位莆田学院; 厦门大学