A polymorphism in HLA-G modifies statin benefit in asthma

作者：Naidoo D; Wu A C; Brilliant M H; Denny J; Ingram C; Kitchner T T; Linneman J G; McGeachie M J; Roden D M; Shaffer C M; Shah A; Weeke P; Weiss S T; Xu H; Medina M W^*

来源：The Pharmacogenomics Journal, 2015, 15(3): 272-277.

DOI：10.1038/tpj.2014.55

Several reports have shown that statin treatment benefits patients with asthma; however, inconsistent effects have been observed. The mir-152 family (148a, 148b and 152) has been implicated in asthma. These microRNAs suppress HLA-G expression, and rs1063320, a common SNP in the HLA-G 3'UTR that is associated with asthma risk, modulates miRNA binding. We report that statins upregulate mir-148b and 152, and affect HLA-G expression in an rs1063320-dependent fashion. In addition, we found that individuals who carried the G minor allele of rs1063320 had reduced asthma-related exacerbations (emergency department visits, hospitalizations or oral steroid use) compared with non-carriers (P = 0.03) in statin users ascertained in the Personalized Medicine Research Project at the Marshfield Clinic (n = 421). These findings support the hypothesis that rs1063320 modifies the effect of statin benefit in asthma, and thus may contribute to variation in statin efficacy for the management of this disease.

• 出版日期2015-6