Alkylation of SH-Heterocycles with Diethyl Phosphite Using Tetrachloroethylene as an Efficient Solvent

作者:Quan Zheng Jun*; Ren Rong Guo; Da Yu Xia; Zhang Zhang; Wang Xi Cun
来源:Heteroatom Chemistry, 2011, 22(5): 653-658.
DOI:10.1002/hc.20729

摘要

Treatment of mercapto-heterocyclic compounds with diethyl phosphite in the presence of 4-dimethylaminopyridine (DMAP) in tetrachloroethylene has given the S-ethylated product in good yields and high chemoselectivity. This procedure is compatible with a wide range of SH-compounds such as 1,3,4-oxadiazole-2-thiol, 1,3,4-thiadiazole-2-thiol, benzo[d]thiazole-2-thiol, and substituted benzenethiol.

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