Potassium Hydroxide/Dimethyl Sulfoxide Promoted Intramolecular Cyclization for the Synthesis of Benzimidazol-2-ones

作者：Beyer Astrid; Reucher Christine M M; Bolm Carsten^*

来源：Organic Letters, 2011, 13(11): 2876-2879.

DOI：10.1021/ol2008878

A new protocol for intramolecular N-arylations of ureas to form benzimidazol-2-ones has been developed. The cyclization reaction occurs In the presence of KOH and DMSO at close to ambient temperature. Under these conditions the yields are high and a wide range of functional groups are tolerated.

• 出版日期2011-6-3