Asymmetric Reduction of Monoketo Hexadecanoic Acid Methyl Esters

作者：Turker Gulen^*; Yusufoglu Ayse

来源：Asian Journal of Chemistry, 2013, 25(3): 1531-1535.

• Reduction
• Enantiometric excess
• Keto hexadecanoates

Methyl 2-,3-,6-,8-,14- and 15-keto hexadecanoates were reduced by using NaBH4 in presence of 1,2;5,6-di-O-isopropilydene-D-glucofuranose [DIPGH], R(+)-1,1%26apos;-binaphthyl-2,2%26apos;-diol [RBND] and pivalic acid [PA]. The reduction of 2- and 3-keto esters in the presence of (+)-1,1%26apos;-binaphthyl-2,2%26apos;-diol results in considerably higher stereoselectivities (95 % ee). Enantiometric excess (ee %) was determined by H-1 and C-13 NMR analyses using a shift reagent, Eu(tfc)(3).

• 出版日期2013-2