A TSP-1 synthetic peptide inhibits bleomycin-induced lung fibrosis in mice

作者：Chen Ying; Wang Xin; Weng Dong; Tian Lujia; Lv Lina; Tao Shasha; Chen Jie^*

来源：Experimental and Toxicologic Pathology, 2009, 61(1): 59-65.

DOI：10.1016/j.etp.2008.04.010

• Lung fibrosis
• Thrombospondin-1 synthetic peptide
• Activation
• Latent TGF-beta 1
• Bleomycin

Bleomycin showed toxicity to lung and was recognized to induce a well model of lung fibrosis. Activated alveolar macrophages released increased amounts of transforming growth factor-beta 1 (TGF-beta 1) in response to bleomycin-induced induced lung injury. Thrombospondin-1(TSP-1) was involved in the activation of latent TGF-beta 1(L-TGF-beta 1) through the association of the TSP-1/L-TGF-beta 1 complex with the cell receptor of TSP-1. CD36. The antagonistic effects of the synthetic peptides were Studied by the administration of TSP-1 (447-452) synthetic peptides to the mouse model. The hydroxyproline contents of the TSP-1-treated groups were significantly lower than those of other experimental groups. Inflammation. fibrotic degree and distribution of colla-en fibers in the interstitial and alveolar in the TSP-1-treated groups were less than those of the other experimental groups. The expressions of collagen I and III in TSP-1-treated groups were significantly lower than in the other experimental groups. TSP-1 synthetic peptide reduced the tissue fibrotic pathologies and collagen accumulation in the model, resulting in the decreased severity of bleomycin-induced lung Injury.

• 出版日期2009-1
• 单位中国医科大学