Acid ionic liquid promoted addition of C(sp(3))-H bond to aldehyde

作者:Zhang Xue Yan; Dong Dao Qing; Yue Tao; Hao Shuang Hong; Wang Zu Li*
来源:Tetrahedron Letters, 2014, 55(40): 5462-5464.
DOI:10.1016/j.tetlet.2014.08.034

摘要

A novel protocol for acid ionic liquid promoted C(sp(3))-H bond functionalization of alkyl azaarenes and nucleophilic addition to aldehydes was developed in good to excellent yields, which provides an efficient approach for the synthesis of alkyl-substituted azaarene derivatives. It is worthwhile to note that acid ionic liquid used for this reaction can be recycled and reused six times without a significant decrease in activity.