Apparent Carbon Monoxide Insertion via Double Isocyanide Incorporation during Palladium-Catalyzed Construction of Indoloquinoline Ring in a Single Pot: Synthesis of New Cytotoxic Agents

作者:Nallapati Suresh Babu; Prasad Bagineni; Sreenivas B Yogi; Sunke Rajnikanth; Poornachandra Y; Kumar C Ganesh; Sridhar B; Shivashankar S; Mukkanti K; Pal Manojit*
来源:Advanced Synthesis & Catalysis, 2016, 358(21): 3387-3393.
DOI:10.1002/adsc.201600599

摘要

The formation of an amide bond via incorporation of two isocyanide units during a palladium-catalyzed construction of the indoloquinoline ring afforded N-substituted 6H-indolo[2,3-b]quinoline-11-carboxamides as new cytotoxic agents. The solvent and base play a key role in the selective and unprecedented synthesis of this class of amides.

  • 出版日期2016-11-3