Emergence of multiple clade 2.3.2.1 influenza A (H5N1) virus subgroups in Vietnam and detection of novel reassortants

作者：Creanga Adrian; Diep Thi Nguyen; Gerloff Nancy; Hoa Thi Do; Balish Amanda; Hoang Dang Nguyen; Jang Yunho; Vui Thi Dam; Thor Sharmi; Jones Joyce; Simpson Natosha; Shu Bo; Emery Shannon; Berman LaShondra; Nguyen Ha T; Bryant Juliet E; Lindstrom Steve; Klimov Alexander; Donis Ruben O; Davis C Todd^*; Tung Nguyen

来源：Virology, 2013, 444(1-2): 12-20.

DOI：10.1016/j.virol.2013.06.005

• Orthomyxovirus
• Highly pathogenic avian influenza virus
• Phylogenetics
• Geographic distribution
• H5N1
• Evolution
• Reassortment

Phylogenetic analyses of 169 influenza A(H5N1) virus genomes were conducted for samples collected through active surveillance and outbreak responses in Vietnam between September 2010 and September 2012. While clade 1.1 viruses persisted in southern regions, three genetically distinct subgroups of clade 2.3.2.1 were found in northern and central Vietnam. The identification of each subgroup corresponded with detection of novel reassortants, likely due to their overlapping circulation throughout the country. While the previously identified clade 1.1 and A/Hubei/1/2010-like 2.3.2.1 genotypes remained the predominant viruses detected, four viruses were found to be reassortants between A/Hubei/1/2010-like (HA, NA, PB2, PB1, PA, NP) and A/duck/Vietnam/NCVD-885/2010-like (M, NS) viruses and one virus was identified as having A/duck/Vietnam/NCVD-885/2010-like HA, NA, PB1, and NP with A/Hubei/1/2010-like PB2 and PA genes. Additionally, clade 23.2.1 A/Hong Kong/6841/2010-like viruses, first detected in mid-2012, were identified as reassortants comprised of A/Hubei/1/2010-like PB2 and PA and A/duck/Vietnam/NCVD-885/2010-like PB1, NP, NA, M, NS genes. Published by Elsevier Inc.

• 出版日期2013-9