科研之友
微信
新浪微博
Facebook
分享链接
摘要
The nickel-catalyzed reduction of secondary and tertiary amides to give amine products is reported. The transformation is tolerant of extensive Variation with respect to the amide substrate, proceeds in the presence of esters and epimerizable stereocenters, and can be used to achieve the reduction of Iactams. Moreover, this methodology provides a simple tactic for accessing medicinally relevant alpha-deuterated amities.
- 出版日期2017-4-7
