科研之友
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摘要
Background Horses are extremely susceptible to ionophore intoxication. Although numerous reports are available regarding monensin, little is known about lasalocid toxicity. Objectives To describe accidental lasalocid poisoning on a farm in Belgium. Animals Eighty-one horses, of which 14 demonstrated clinical signs from day 021 after being fed a new concentrate batch. One horse died on day 20 and another on day 27. Methods The most severe cases (n = 7), admitted to the clinic on day 2946, underwent cardiac examination and blood biochemical analysis, including determination of plasma cardiac troponin I (cTnI) at admission and during follow-up. On day 5770, cardiac examination, cTnI determination or both were undertaken on 72 remaining horses. Results Short-term effects of lasalocid intoxication included inappetance, lethargy, sweating, and muscular weakness. All 7 horses admitted to the clinic demonstrated signs of myocardial degeneration such as increased cTnI, dysrhythmia and reduced myocardial contractility. Four horses developed ataxia on day 4050. Five horses died or were euthanized on day 30370, 2 horses recovered fully and returned to previous athletic use. None of the 72 remaining horses exhibited clinical signs between day 5770, but 34 had dysrhythmia and 13 had increased cTnI concentrations. After a period of rest, all horses returned to their previous work. Lasalocid was detected in hepatic tissue of 2 necropsied horses. Conclusions and Clinical Importance Lasalocid intoxication induced myocardial and neurological damage. Although uncommon, this should be included as differential diagnosis for unexplained inappetance, signs of depression, cardiomyopathy, and ataxia in horses.
- 出版日期2012-8
