科研之友
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摘要
Marijuana is currently the most commonly abused illicit drug. According to recent studies, cannabinoid use occurring prior to pregnancy can impact brain plasticity and behavior in future generations. The purpose of the present study was to determine whether adolescent exposure of female rats to Delta(9)-tetrahydrocannabinol (Delta(9)-THC) induces transgenerational effects on the reward-facilitating effects of Delta(9)-THC and d-amphetamine in their adult male offspring. Female Sprague-Dawley rats received Delta(9)-THC (0.1 or 1 mg/kg, i.p.) or vehicle during postnatal days 28-50. As adults, females were mated with drug-naive males. We then assessed potential alterations of the Delta(9)-THC's (0, 0.1, 0.5, and 1 mg/kg, i.p.) and d-amphetamine's (0, 0.1, 0.5, and 1 mg/kg, i.p.) reward-modifying effects using the curve-shift variant of the intracranial self-stimulation (ICSS) procedure in their adult male F1 offspring. The reward-facilitating effect of the 0.1 mg dose of Delta(9)-THC was abolished in the F1 offspring of females that were exposed to Delta(9)-THC (0.1 or 1 mg/kg), whereas the reward-attenuating effect of the 1 mg dose of Delta(9)-THC remained unaltered. The reward-facilitating effects of 0.5 and 1 mg of d-amphetamine were significantly decreased in the F1 offspring of females that were exposed to Delta(9)-THC (1 mg/kg and 0.1 or 1 mg, respectively). The present results reveal that female Delta(9)-THC exposure during adolescence can diminish the reward-facilitating effects of Delta(9)-THC and d-amphetamine in the adult male offspring. These transgenerational effects occur in the absence of in utero exposure. It is speculated that Delta(9)-THC exposure during female adolescence may affect neural mechanisms that are shaping reward-related behavioral responses in a subsequent generation, as indicated by the shifts in the reward-facilitating effects of commonly used and abused drugs.
- 出版日期2017-4-25
