Aromatic Constituents from the Stems of Astragalus membranaceus (Fisch.) Bge. var. Mongholicus (Bge.) Hsiao

作者：Hao, Jia; Li, Jian; Li, Xiaoxia; Liu, Yanxia; Ruan, Jingya; Dong, Yongzhe; Zhang, Yi^*; Wang, Tao^*

来源：Molecules, 2016, 21(3): 354.

DOI：10.3390/molecules21030354

• Astragalus membranaceus (Fisch.) Bge. var
• mongholicus (Bge.) Hsiao
• stem
• structure elucidation
• aromatic constituents
• L6 cells
• glucose consumption

Four new aromatic constituents, astraflavonoids A (1), B (2), C (3), and astramemoside A (4), along with sixteen known ones 5-20 were obtained from the stems of A. membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao. Their structures were elucidated by chemical and spectroscopic methods. Among the known isolates, 14 was obtained from the Astragalus genus for the first time, while 7-12, 18-20 were isolated from the species for the first time. The effects of the compounds obtained from the plant on glucose consumption were analyzed in differentiated L6 myotubes in vitro, whereby compounds 1, 2, 3, 7, 8, 10, 11, 14, 15 and 18 displayed significant promoting effects on glucose consumption in L6 myotubes. Among them, the activities of 1, 2 and 7 were comparable to that of insulin, which suggested that these compounds may be involved in glucose metabolism and transport.

• 单位
  天津中医药大学