Needling Versus Liquid Nitrogen Cryotherapy for the Treatment of Pedal Warts A Randomized Controlled Pilot Study

作者：Cunningham Daniel J; Brimage Jessica T; Naraghi Reza N; Bower Virginia M^*

来源：Journal of the American Podiatric Medical Association, 2014, 104(4): 394-401.

DOI：10.7547/0003-0538-104.4.394

Background: We hypothesized that needling of a pedal wart creates local inflammation and a subsequent cell-mediated immune response (CMIR) against human papillomavirus. The primary objective of this study was to investigate whether needling to induce a CMIR against human papillomavirus is an effective treatment for pedal warts compared with liquid nitrogen cryotherapy. A secondary objective was to investigate whether the CMIR induced by needling is effective against satellite pedal warts. %26lt;br%26gt;Methods: Eligible patients with pedal warts were randomly allocated to receive either needling or liquid nitrogen cryotherapy. Only the primary pedal wart was treated during the study. Follow-up was 12 weeks, with outcome assessments made independently under blinded circumstances. %26lt;br%26gt;Results: Of 37 patients enrolled in the study, 18 were allocated to receive needling and 19 to receive liquid nitrogen cryotherapy. Regression of the primary pedal wart occurred in 64.7% of the needling group (11 of 17) and in 6.2% of the liquid nitrogen cryotherapy group (1 of 16) (P = .001). No significant relationship was found between needling of the primary pedal wart and regression of satellite pedal warts (P = .615) or complete pedal wart regression (P = .175). There was no significant difference in pain, satisfaction, or cosmesis between the two groups. %26lt;br%26gt;Conclusions: The regression rate of the primary pedal wart was significantly higher in the needling group compared with the liquid nitrogen cryotherapy group.

• 出版日期2014-8