A 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 confers protections against HIV-1 infection

作者：Biasin Mara; Sironi Manuela; Saulle Irma; Pontremoli Chiara; Garziano Micaela; Cagliani Rachele; Trabattoni Dania; Lo Caputo Sergio; Vichi Francesca; Mazzotta Francesco; Forni Diego; Riva Stefania; Aguilar Jimenez Wbeimar; Cedeno Samandhy; Sanchez Jorge; Brander Christian; Zapata Wildeman; Teresa Rugeles Maria; Clerici Mario

来源：Microbes and Infection, 2017, 19(1): 69-74.

DOI：10.1016/j.micinf.2016.09.005

• HIV
• HESN
• TIM-1
• Polymorphism
• Resistance to infection

We investigated whether a 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 (T-cell immunoglobulin and mucin domain 1), modulates susceptibility to HIV-1 infection. The polymorphism was genotyped in three case/control cohorts of HIV-1 exposed seronegative individuals (HESN) and HIV-1 infected subjects from Italy, Peru, and Colombia; data from a Thai population were retrieved from the literature. Across all cohorts, homozygosity for the short TIM-1 allele was more common in HESNs than in HIV-1 infected subjects. A meta analysis of the four association analyses yielded a p value of 0.005. In vitro infection assays of CD4+ T lymphocytes indicated that homozygosity for the short allele is associated with lower rate of HIV-1 replication. These results suggest that the deletion allele protects from HIV-1 infection with a recessive effect.

• 出版日期2017-1