Asymmetric Cyanation of Activated Olefins with Ethyl Cyanoformate Catalyzed by a Modular Titanium Catalyst

作者：Wang, Jun; Li, Wei; Liu, Yanling; Chu, Yangyang; Lin, Lili; Liu, Xiaohua; Feng, Xiaoming^*

来源：Organic Letters, 2010, 12(6): 1280-1283.

DOI：10.1021/ol100169r

• ENANTIOSELECTIVE CONJUGATE ADDITION
• CYANO-ETHOXYCARBONYLATION REACTION
• ALPHA,BETA-UNSATURATED IMIDES
• CYANOHYDRIN SYNTHESIS
• ACHIRAL ADDITIVES
• STRECKER REACTION
• RATIONAL DESIGN
• ALDEHYDES
• COMPLEX
• KETIMINES

Asymmetric cyanation of a class of easily available olefins with a favorable cyanide source ethyl cyanoformate (CNCOOEt) was realized by an interesting modular catalyst. High yields and ee values were obtained for a range of substrates under solvent-free and mild reaction conditions. The products obtained could be easily transformed to the enantioenriched useful intermediates 5, 6, and pharmaceutically important gamma-aminobutyric acid 7.

• 出版日期2010-3-19
• 单位四川大学