A study of nucleotide sequence variability of rha locus genes of Yersinia pestis main and nonmain subspecies

作者：Koukleva L M^*; Eroshenko G A; Kouklev V E; Shavina N Yu; Krasnov Ya M; Guseva N P; Kutyrev V V

来源：Molecular Genetics, Microbiology and Virology, 2008, 23(2): 77-82.

DOI：10.3103/S0891416808020043

A study of the structural and regulatory genes that determine rhamnose fermentation, which are located in the rha locus of the chromosome of Yersinia pestis main and nonmain subspecies and of the Yersinia pseudotuberculosis of serogroups I-III was performed. The nucleotide sequence of main subspecies of Y. pestis differs substantially from those of nonmain subspecies and Y. pseudotuberculosis by the presence of a nucleotide substitution in 671 bp location of rhaS gene, resulting presumably in the inability of the Y. pestis nonmain subspecies to utilize rhamnose. Other nucleotide substitutions found in Y. pestis nonmain subspecies strains influence only the expression efficiency of this diagnostic criterion.

• 出版日期2008-6