Agents of Last Resort Polymyxin Resistance

作者:Kaye Keith S; Pogue Jason M; Tran Thien B; Nation Roger L; Li Jian
来源:Infectious Disease Clinics of North America, 2016, 30(2): 391-+.
DOI:10.1016/j.idc.2016.02.005

摘要

Polymyxin resistance is a major public health threat, as the polymyxins represent "last-line" therapeutics for Gram-negative pathogens resistant to essentially all other antibiotics. Improved understanding of mechanisms of, and risk factors for, polymyxin resistance, as well as infection prevention and stewardship strategies, together with optimization of dosing of polymyxins including in combination regimens, can help to limit the emergence and dissemination of polymyxin resistance.

  • 出版日期2016-6