An improved synthesis of beta-nicotyrine from the dehydrogenation of nicotine: Comparison of conventional and microwave-assisted reactions

作者：Wei XC; Crooks PA^*

来源：Synthetic Communications, 2003, 33(19): 3305-3315.

DOI：10.1081/SCC-120023988

• beta-nicotyrine
• nicotine
• dehydrogenation
• microwave irradiation

beta-Nicotyrine, a minor tobacco alkaloid, can be rapidly prepared in good yield from the dehydrogenation of S-(-)-nicotine over MnO2 with microwave irradiation. This method is superior to dehydrogenation reactions that utilize S-(-)-nicotine and MnO2 in a variety of solvents under reflux.

• 出版日期2003