Modular synthesis of 4-aminocarbonyl substituted 1,8-naphthalimides and application in single molecule fluorescence detection

作者：Hearn K N; Nalder T D; Cox R P; Maynard H D; Bell T D M; Pfeffer F M; Ashton T D^*

来源：Chemical communications, 2017, 53(91): 12298-12301.

DOI：10.1039/c7cc07922b

Robust methodology to install amide, carbamate, urea and sulfonamide functionality to the 1,8-naphthalimide scaffold has been developed and exemplified. New benzamidonaphthalimide 6, synthesised using this approach, was found to be sensitive to base whereupon fluorescence emission strongly increases (> 10-fold) and red-shifts (> 4000 cm(-1)). The optical properties of deprotonated 6 allow for single molecule fluorescence detection, the first example of such behaviour from this class of fluorophore.

• 出版日期2017-11-25
• 单位迪肯大学