Affinity-based release of polymer-binding peptides from hydrogels with the target segments of peptides

作者:Serizawa Takeshi*; Fukuta Hiroki; Date Takaaki; Sawada Toshiki
来源:Chemical communications, 2016, 52(11): 2241-2244.
DOI:10.1039/c5cc09016d

摘要

Peptides with affinities for the target segments of polymer hydrogels were identified by biological screening using phage-displayed peptide libraries, and these peptides exhibited an affinity-based release capability from hydrogels. The results from cell culture assays demonstrated the sustained anticancer effects of the drug-conjugated peptides that were released from the hydrogels.

  • 出版日期2016