A Convenient and Facile Synthesis of Isoxazolyl-chromeno[4,3,2-de]pyrimido[4,5-h][1,6]napthyridinones

作者：Rajanarendar Eligeti^*; Ramakrishna Saini; Kishore Baireddy

来源：Journal of Heterocyclic Chemistry, 2014, 51(5): 1415-1420.

DOI：10.1002/jhet.1836

The ceric ammonium nitrate-catalyzed synthesis of (E)-5-amino-N-(3-methyl-5-styrylisoxazol-4-yl)-2-arylchromeno[4,3,2-de][1,6]napthyridin-4-carboxamides 5 was simply achieved upon the one-pot four-component reaction of isoxazolyl cyanoacetamide 1 with malononitrile 2, 2-hydroxy acetophenone 3, and aromatic aldehydes 4 in ethanol. Compounds 5 on heating with acetic anhydride underwent tandem N-acetylation and cyclocondensation involving intramolecular cyclization to afford the title compounds (E)-11-methyl-12-(3-methyl-5-styrylisoxazol-4-yl)-2-arylchromeno[4,3,2-de][1,6]napthyridin-13(12H)-ones 6 in good yields. The chemical structures have been confirmed by analytical and spectral analyses.

• 出版日期2014-9