Association of Serum Omentin-1 Concentrations with the Presence of Atrial Fibrillation

作者：Tao, Sha; Huang, Yu-Qing; Cai, An-Ping; Huang, Cheng; Zhang, Ying; Tang, Song-Tao; Yu, Xue-Ju; Zhou, Dan; Tan, Ning^*; Feng, Ying-Qing^*

来源：MEDICAL SCIENCE MONITOR, 2016, 22: 4749-4754.

DOI：10.12659/MSM.898202

• Adipokines
• Atrial Fibrillation
• Inflammation Mediators
• Obesity Hypoventilation Syndrome

Background: Omentin-1 is one of the adipokines associated with obesity, diabetes, and coronary heart disease development. We determined to investigate whether serum omentin-1 concentrations were correlated with the presence of atrial fibrillation (AF).
Material/Methods: Serum omentin-1 concentrations were examined in a cross-sectional population that included 220 patients with AF (70 with paroxysmal AF, 78 with persistent AF, and 72 with permanent AF) and 115 healthy controls.
Results: Reduced serum omentin-1 concentrations were found in AF patients compared to the controls. In addition, patients with permanent AF had lower serum omentin-1 concentrations compared to patients with persistent AF and patients with paroxysmal AF. Significantly decreased serum omentin-1 concentrations were observed in persistent AF patients compared to paroxysmal AF patients. Spearman correlation analysis suggested that serum omentin-1 concentrations were negatively correlated with left atrial diameter in AF patients.
Conclusions: Serum omentin-1 concentrations were correlated with the presence of AF and atrial remolding.

• 出版日期2016-12-4
• 单位广东省人民医院; 南方医科大学; 广东省心血管病研究所