Molecular Signatures of the Three Stem Cell Lineages in Hydra and the Emergence of Stem Cell Function at the Base of Multicellularity

作者：Hemmrich Georg; Khalturin Konstantin; Boehm Anna Marei; Puchert Malte; Anton Erxleben Friederike; Wittlieb Joerg; Klostermeier Ulrich C; Rosenstiel Philip; Oberg Hans Heinrich; Domazet Loso Tomislav; Sugimoto Toshimi; Niwa Hitoshi; Bosch Thomas C G^*

来源：Molecular Biology and Evolution, 2012, 29(11): 3267-3280.

DOI：10.1093/molbev/mss134

• aging
• adult stem cell
• self-renewal
• differentiation
• evolution

How distinct stem cell populations originate and whether there is a clear stem cell "genetic signature" remain poorly understood. Understanding the evolution of stem cells requires molecular profiling of stem cells in an animal at a basal phylogenetic position. In this study, using transgenic Hydra polyps, we reveal for each of the three stem cell populations a specific signature set of transcriptions factors and of genes playing key roles in cell type-specific function and interlineage communication. Our data show that principal functions of stem cell genes, such as maintenance of stemness and control of stem cell self-renewal and differentiation, arose very early in metazoan evolution. They are corroborating the view that stem cell types shared common, multifunctional ancestors, which achieved complexity through a stepwise segregation of function in daughter cells.

• 出版日期2012-11