Maedamide, a novel chymotrypsin inhibitor from a marine cyanobacterial assemblage of Lyngbya sp.

作者：Iwasaki Arihiro; Ohno Osamu; Sumimoto Shinpei; Suda Shoichiro; Suenaga Kiyotake^*

来源：Tetrahedron Letters, 2014, 55(30): 4126-4128.

DOI：10.1016/j.tetlet.2014.05.099

• Maedamide
• Marine cyanobacteria
• Depsipeptide
• Chymotrypsin inhibitor
• Lyngbya

Maedamide, a novel chymotrypsin-inhibiting depsipeptide, was isolated from a cyanobacterial assemblage that mostly consisted of Lyngbya sp. Its structure was elucidated by spectroscopic analyses and chiral HPLC analyses of hydrolysis products. Maedamide selectively inhibited chymotrypsin but not elastase and trypsin. In addition, Maedamide strongly inhibited the growth of HeLa cells and HL60 cells.

• 出版日期2014-7-23