Asymmetric total synthesis of (-)-venlafaxine using an organocatalyst

作者：Chavan Subhash P^*; Garai Sumanta; Pawar Kailash P

来源：Tetrahedron Letters, 2013, 54(17): 2137-2139.

DOI：10.1016/j.tetlet.2013.02.029

• Antidepressent
• Organocatalyst
• Asymmetric synthesis
• Venlafaxine
• Michael addition

An asymmetric total synthesis of (-)-venlafaxine using an organocatalyst has been achieved via a unified strategy employing organcatalytic Michael addition, regio-selective dehydration and selective epoxide ring opening.

• 出版日期2013-4-24