A naproxen complex of dysprosium intercalates into calf thymus DNA base pairs

作者：Yang, Mengsi; Jin, Jianhua; Xu, Guiqing; Cui, Fengling^*; Luo, Hongxia

来源：Chemical Physics, 2014, 428: 1-5.

DOI：10.1016/j.chemphys.2013.10.013

• Dysprosium-naproxen complex
• Intercalative binding
• ctDNA
• Interaction
• Fluorescence spectroscopy

The binding mode and mechanism of dysprosium-naproxen complex (Dy-NAP) with calf thymus deoxyribonucleic acid (ctDNA) were studied using UV-vis and fluorescence spectra in physiological buffer (pH 7.4). The results showed that more than one type of quenching process occurred and the binding mode between Dy-NAP with ctDNA might be intercalation. In addition, ionic strength, iodide quenching and fluorescence polarization experiments corroborated the intercalation binding mode between Dy-NAP and ctDNA. The calculated thermodynamic parameters Delta G, Delta H and Delta S at different temperature demonstrated that hydrophobic interaction force played a major role in the binding process.

• 出版日期2014-1-15
• 单位中国人民大学; 河南师范大学