Antifungal effect with apoptotic mechanism(s) of Styraxjaponoside C

作者：Park Cana; Woo Eun Rhan; Lee Dong Gun^*

来源：Biochemical and Biophysical Research Communications, 2009, 390(4): 1255-1259.

DOI：10.1016/j.bbrc.2009.10.131

• Styraxjaponoside C
• Styrax japonica S. et Z
• Lignans
• Antifungal activity
• Apoptosis

The antifungal effects and mechanisms of Styraxjaponoside C were investigated. Styraxjaponoside C was active against several human pathogens, including Candida albicans. Styraxjaponoside C induced a series of cellular changes characteristic of apoptosis in C. albicans, including increased reactive oxygen species (ROS) production, measured by DHR-123 staining; phosphatidylserine externalization, visualized by Annexin V staining: DNA fragmentation, as seen by TUNEL; and plasma membrane depolarization, observed by DiBAC(4)(3) staining. The plasma membrane depolarization is likely to be associated with production of ROS. The current study suggests that Styraxjaponoside C exerts an antifungal effect by promoting apoptosis.

• 出版日期2009-12-25