Lack of association of the ACE genotype with the muscle strength response to resistance training

作者：Gentil Paulo^*; Lima Ricardo M; Pereira Rinaldo Wellerson; Mourot Julia; Leite Tailce Kaley; Bottaro Martim

来源：European Journal of Sport Science, 2012, 12(4): 331-337.

DOI：10.1080/17461391.2011.573581

• Genetics
• exercise
• candidate gene
• muscle strength
• peak torque
• strength training

Introduction: Previous studies have attempted to link the insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene with the variability in muscle strength responses to resistance training (RT); however, the literature is inconclusive. The purpose of the present study was to investigate the association between the ACE I/D genotype and muscle strength response to a RT program in young men. %26lt;br%26gt;Methods: 124 men (22 +/- 2.6 years; 174.8 +/- 6.5cm; 71.5 +/- 13.8 kg) without resistance training experience were tested before and after 11 weeks of five whole-body RT exercises (bench press, seated row, knee extension, knee flexion and sit ups). The bench press 1RM test was used to assess upper-body muscle strength and the isokinetic knee extensor peak torque (PT) was used as a measure of lower-body strength. %26lt;br%26gt;Results: At baseline, there were no differences among ACE genotype for 1RM load (54 +/- 11.7 kg for II, 58.5 +/- 8.9 kg for ID and 52.3 +/- 12.2 kg for DD) or knee extensor peak torque (PT) (220.1 +/- 36.8 N.m for II, 209.4 +/- 44.4 N.m for ID and 199.7 +/- 32.4 N.m for DD). Moreover, ACE genotype was not associated with lower-body (7.1 +/- 10.5%, 15.7 +/- 10.4% and 14.1 +/- 22.7% for II, ID and DD, respectively) or upper-body strength gains (16.2 +/- 8.9%, 14.5 +/- 11.3% and 21.9 +/- 17.1% for II, ID and DD, respectively) in response to RT. %26lt;br%26gt;Conclusion: The ACE I/D genotype was not associated with the muscle strength responses to RT.

• 出版日期2012