Determination of sedatives and adrenergic blockers in blood meal using accelerated solvent extraction and Orbitrap mass spectrometry

作者：Choi Jeong Heui; Lamshoeft Marc; Zuehlke Sebastian; Park Ki Hun; Shim Jae Han^*; Spiteller Michael

来源：Journal of Chromatography A, 2012, 1260: 111-119.

DOI：10.1016/j.chroma.2012.08.060

• Sedatives
• alpha-, beta-blockers
• Accelerated solvent extraction
• Dispersive solid-phase extraction
• Orbitrap mass spectrometry
• Environment-friendly agricultural material

The detection of veterinary drugs in blood meal is needed since it is used as an environment-friendly agricultural material despite its origination from animal blood. A method using accelerated solvent extraction and liquid chromatographic linear ion trap quadrupole Orbitrap mass spectrometry was developed to determine sedatives and adrenergic blockers in blood meal. The determination method was established following optimizations of accelerated solvent extraction, dispersive solid-phase extraction and high resolution mass spectrometric detection. Linearity, sensitivity, accuracy, repeatability and reproducibility of the method were fully validated. The method was applied to commercial blood meal products.

• 出版日期2012-10-19