Alzheimer's disease genetics: lessons to improve disease modelling

作者：Guerreiro Rita J; Hardy John^*

来源：Biochemical Society Transactions, 2011, 39(4): 910-916.

DOI：10.1042/BST0390910

• Alzheimer's disease
• amyloid beta-peptide
• complement system
• disease modelling
• genome-wide association study (GWAS)
• lipid metabolism

In the present review, we look back at the recent history of GWAS (genome-wide association studies) in AD (Alzheimer's disease) and integrate the major findings with current knowledge of biological processes and pathways. These topics are essential for the development of animal models, which will be fundamental to our complete understanding of AD.

• 出版日期2011-8