A Simple Modified Framingham Scoring System to Predict Obstructive Coronary Artery Disease

作者：Liu, Yong; Li, Qiang; Chen, Shiqun; Wang, Xia; Zhou, Yingling; Tan, Ning; Chen, Jiyan^*

来源：Journal of Cardiovascular Translational Research, 2018, 11(6): 495-502.

DOI：10.1007/s12265-018-9837-6

• Prediction model
• Risk factors
• Coronary artery disease
• China
• Validation

Development of simple non-invasive risk prediction model would help in early prediction of coronary artery disease (CAD) reducing the burden on public health. This paper demonstrates a risk prediction scoring system to predict obstructive coronary artery disease (OCAD) in CAD patients. A total of 13,082 patients, referred for coronary angiography (CAG) in TRUST trial, were included in the development of a multivariable diagnostic prediction model. External validation of the model used 1009 patients from PRECOMIN study. The occurrence of OCAD was observed in 73.1% and 75.1% patients in TRUST (development) and PRECOMIN study (validation) cohorts, respectively. Good discrimination and calibration were obtained in both development and validation datasets (C-statistics 0.686 and 0.677; Hosmer-Lemeshow (2)=5.19, p=0.74 and (2)=8.60, p=0.38, respectively). The simple risk prediction model and risk scoring system developed on the basis of routine clinical variables showed good performance for estimation of OCAD in relative high-risk patients with suspected CAD.

• 出版日期2018-12
• 单位广东省心血管病研究所; 广东省人民医院