An improvement in the calculation of the efficiency of oxidative phosphorylation and rate of energy dissipation in mitochondria

作者：Ghafuri Mohazabeh^*; Golfar Bahareh; Nosrati Mohsen; Hoseinkhani Saman

来源：Journal of Non-Equilibrium Thermodynamics, 2014, 39(4): 175-182.

DOI：10.1515/jnet-2014-0005

• Non-equilibrium thermodynamics
• oxidative phosphorylation
• adenosine triphosphate
• proton pumps

The process of ATP production is one of the most vital processes in living cells which happens with a high efficiency. Thermodynamic evaluation of this process and the factors involved in oxidative phosphorylation can provide a valuable guide for increasing the energy production efficiency in research and industry. Although energy transduction has been studied qualitatively in several researches, there are only few brief reviews based on mathematical models on this subject. In our previous work, we suggested a mathematical model for ATP production based on non-equilibrium thermodynamic principles. In the present study, based on the new discoveries on the respiratory chain of animal mitochondria, Golfar%26apos;s model has been used to generate improved results for the efficiency of oxidative phosphorylation and the rate of energy loss. The results calculated from the modified coefficients for the proton pumps of the respiratory chain enzymes are closer to the experimental results and validate the model.

• 出版日期2014-12