Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

作者：Kalra Hina^*; Simpson Richard J; Ji Hong; Aikawa Elena; Altevogt Peter; Askenase Philip; Bond Vincent C; Borras Francesc E; Breakefield Xandra; Budnik Vivian; Buzas Edit; Camussi Giovanni; Clayton Aled; Cocucci Emanuele; Falcon Perez Juan M; Gabrielsson Susanne; Gho Yong Song; Gupta Dwijendra; Harsha H C; Hendrix An; Hill Andrew F; Inal Jameel M; Jenster Guido; Kraemer Albers Eva Maria; Lim Sai Kiang; Llorente Alicia; Lotvall Jan; Marcilla Antonio

来源：PLOS BIOLOGY, 2012, 10(12): e1001450.

DOI：10.1371/journal.pbio.1001450

Extracellular vesicles (EVs) are membraneous vesicles released by a variety of cells into their microenvironment. Recent studies have elucidated the role of EVs in intercellular communication, pathogenesis, drug, vaccine and gene-vector delivery, and as possible reservoirs of biomarkers. These findings have generated immense interest, along with an exponential increase in molecular data pertaining to EVs. Here, we describe Vesiclepedia, a manually curated compendium of molecular data (lipid, RNA, and protein) identified in different classes of EVs from more than 300 independent studies published over the past several years. Even though databases are indispensable resources for the scientific community, recent studies have shown that more than 50% of the databases are not regularly updated. In addition, more than 20% of the database links are inactive. To prevent such database and link decay, we have initiated a continuous community annotation project with the active involvement of EV researchers. The EV research community can set a gold standard in data sharing with Vesiclepedia, which could evolve as a primary resource for the field.

• 出版日期2012-12
• 单位上海生物信息技术研究中心; 河北医科大学