Adenovirus DNA in Guthrie cards from children who develop acute lymphoblastic leukaemia (ALL)

作者：Honkaniemi E; Talekar G; Huang W; Bogdanovic G; Forestier E; von Doblen U; Engvall M; Ornelles D A; Gooding L R; Gustafsson B^*

来源：British Journal of Cancer, 2010, 102(5): 796-798.

DOI：10.1038/sj.bjc.6605581

• aetiology
• childhood leukaemia
• adenovirus
• prenatal infection

BACKGROUND: In search of a proposed viral aetiology of childhood acute lymphoblastic leukaemia (ALL), the common species C adenoviruses were analysed in Guthrie cards.
METHODS: Guthrie cards from 243 children who later developed ALL and from 486 matched controls were collected and analysed by nested polymerase chain reaction for the presence of adenovirus DNA.
RESULTS: Adenovirus DNA was reliably detected from only two subjects, both of whom developed ALL.
CONCLUSION: Adenovirus DNA is detected in Guthrie card samples at too low a frequency to reveal an association between adenovirus and the development of leukaemia. British Journal of Cancer (2010) 102, 796 - 798. doi: 10.1038/sj.bjc.6605581 www.bjcancer.

• 出版日期2010-3-2