Association study between catechol-O-methyltransferase polymorphisms and uterine leiomyomas in a Japanese population

作者：Morikawa J; Yoshida S^*; Kennedy S; Takemura N; Sugimoto M; Kitao K; Deguchi M; Ohara N; Maruo T

来源：Clinical and Experimental Obstetrics & Gynecology, 2008, 35(1): 35-40.

• leiomyoma
• gene polymorphism
• polymerase chain reaction
• restriction fragment length polymorphism
• catechol-O-methyltransferase

Purpose: To investigate a possible association between uterine leiomyomas and catechol-O-methyltransferase (COMT) polymorphisms in a Japanese population. Methods: We compared the allele frequencies and genotype distributions of the exon 4 NlaIII restriction site polymorphism (RSP), the P2 promoter HindIII RSP at - 1217, and the exon 6 BglI RSP in the COMT gene in 250 leiomyoma cases and 182 controls using polymerase chain reaction-restriction fragment-length polymorphism analysis. Results: No significant differences in allele frequencies and genotype distributions of the exon 4 NlaIII RSP, the P2 promoter HindIII RSP at 1217, and the exon 6 BglI RSP were found between uterine leiomyoma cases and controls. Moreover, no associations were noted between these three polymorphisms in COMT genes and leiomyoma size or a family history of uterine leiomyomas. Conclusion: COMT gene polymorphisms are unlikely to be associated with an increased risk of uterine leiomyomas in a Japanese population.

• 出版日期2008