Daphmanidins C and D, novel pentacyclic alkaloids from Daphniphyllum teijsmanii

作者:Morita H*; Ishioka N; Takatsu H; Shinzato T; Obara Y; Nakahata N; Kobayashi J
来源:Organic Letters, 2005, 7(3): 459-462.
DOI:10.1021/ol047641+

摘要

Two novel alkaloids with an unprecedented fused-pentacyclic skeleton, daphmanidins C (1) and D (2), have been isolated from the leaves of Daphniphyllum teijsmanii, and the structures were elucidated on the basis of spectroscopic data. The relative stereochemistry of I and 2 was assigned by combination of NOESY correlations and a simulation analysis. Daphmanidin C (1) elevated activity of NGF biosynthesis.

  • 出版日期2005-2-3