Mulberry Water Extracts Inhibit Rabbit Atherosclerosis through Stimulation of Vascular Smooth Muscle Cell Apoptosis via Activating p53 and Regulating Both Intrinsic and Extrinsic Pathways

作者：Chan Kuei Chuan; Ho Hsieh Hsun; Lin Ming Cheng; Wu Cheng Hsun; Huang Chien Ning; Chang Wen Chun; Wang Chau Jong^*

来源：Journal of Agricultural and Food Chemistry, 2014, 62(22): 5092-5101.

DOI：10.1021/jf501466t

• atherosclerosis
• vascular smooth muscle cells
• mulberry water extracts
• p53
• intrinsic pathway
• extrinsic pathway

Previous studies have shown that mulberry water extracts (MWEs), which contain polyphenolic compounds, have an antiatherosclerotic effect in rabbits. Apoptosis of vascular smooth muscle cells (VSMCs) is the key determinant of the number of VSMCs in remodeling. To improve the recovery from atherosclerosis pathology, it would be ideal to induce regression of atherosclerotic plaques and apoptosis of VSMCs. In this study, we treated high-cholesterol-diet-fed (HCD-fed) rabbits with NWEs, and we found that the MWEs effectively inhibited HCD-fed-induced intimal hyperplasia of vessel walls. We also found that MWEs initially activate JNK/p38 and p53, which in turn activate both Fas-ligand and mitochondria pathways, thereby causing mitochondria translocation of Bax and the reduction of Bcl-2 that trigger the cleavage of procaspases, finally resulting in apoptosis of VSMCs. In addition, 2.5-5.0 g/day of MWEs for humans may be enough to prevent atherosclerosis.

• 出版日期2014-6-4
• 单位中国医科大学; 河北医科大学