mTOR couples cellular nutrient sensing to organismal metabolic homeostasis

作者：Howell Jessica J; Manning Brendan D^*

来源：Trends in Endocrinology and Metabolism, 2011, 22(3): 94-102.

DOI：10.1016/j.tem.2010.12.003

The mammalian target of rapamycin complex 1 (mTORC1) has the ability to sense a variety of essential nutrients and respond by altering cellular metabolic processes. Hence, this protein kinase complex is poised to influence adaptive changes to nutrient fluctuations toward the maintenance of whole-body metabolic homeostasis. Defects in mTORC1 regulation, arising from either physiological or genetic conditions, are believed to contribute to the metabolic dysfunction underlying a variety of human diseases, including type 2 diabetes. We are just now beginning to gain insights into the complex tissue-specific functions of mTORC1. In this review, we detail the current knowledge of the physiological functions of mTORC1 in controlling systemic metabolism, with a focus on advances obtained through genetic mouse models.

• 出版日期2011-3