New rubrolide analogues as inhibitors of photosynthesis light reactions

作者：Varejao Jodieh O S; Barbosa Luiz C A^*; Alvarez Ramos Gabriela; Varejao Eduardo V V; King Diaz Beatriz; Lotina Hennsen Blas

来源：Journal of Photochemistry and Photobiology B: Biology , 2015, 145: 11-18.

DOI：10.1016/j.jphotobiol.2015.02.016

Natural products called rubrolides have been investigated as a model for the development of new herbicides that act on the photosynthesis apparatus. This study comprises a comprehensive analysis of the photosynthesis inhibitory ability of 27 new structurally diverse rubrolide analogues. In general, the results revealed that the compounds exhibited efficient inhibition of the photosynthetic process, but in some cases low water solubility may be a limiting factor. To elucidate their mode of action, the effects of the compounds on PSII and PSI, as well as their partial reaction on chloroplasts and the chlorophyll a fluorescence transients were measured. Our results showed that some of the most active rubrolide analogues act as a Hill reaction inhibitors at the QB level by interacting with the D1 protein at the reducing side of PSI!. All of the active analogues follow Tice's rule of 5, which indicates that these compounds present physicochemical properties suitable for herbicides.

• 出版日期2015-4