An antimicrobial diketopiperazine alkaloid and co-metabolites from an endophytic strain of Gliocladium isolated from Strychnos cf. toxifera

作者：Ferreira Koolen Hector Henrique; Soares Elzalina Ribeiro; Araujo da Silva Felipe Moura; Lima de Souza Antonia Queiroz; de Medeiros Livia Soman; Rodrigues Filho Edson; de Almeida Richardson Alves; Ribeiro Ismael Alexandre; Pessoa Claudia do O; de Morais Manoel Odorico; da Costa Patricia Marcal; Leao de Souza Afonso Duarte

来源：Natural Product Research, 2012, 26(21): 2013-2019.

DOI：10.1080/14786419.2011.639070

• Gliocladium sp.
• Strychnos cf. toxifera
• Micrococcus luteus
• cytotoxicity

From an endophytic strain of Gliocladium sp. isolated from the Amazonian plant Strychnos cf. toxifera, we obtained the diketopiperazine alkaloid cyclo-(glycyl-L-tyrosyl)-4,4-dimethylallyl ether (1), the steroids ergosterol (2), ergosterol peroxide (3), cerevisterol (4) and the citric acid (5). The AcOEt extract of the fermented broth by Gliocladium sp. showed potent activity against the cancer cell lines MDA-MB435 (human breast cancer cells), HCT-8 (human colorectal cancer cells) and SF-295 (human glioblastoma cancer cells). Compound 1 exhibited a strong antimicrobial activity against Micrococcus luteus at a concentration of 43.4 mu M.

• 出版日期2012