Application of the Crystalline Sponge Method to Revise the Structure of the Phenalenone Fuliginone

作者：Brkljaca Robert; Schneider Bernd; Hidalgo William; Otalvaro Felipe; Ospina Felipe; Lee Shoukou; Hoshino Manabu; Fujita Makoto; Urban Sylvia

来源：Molecules, 2017, 22(2): 211.

DOI：10.3390/molecules22020211

• fuliginone
• phenylphenalenone
• synthesis
• crystalline sponge method
• HPLC-NMR

The structure of fuliginone was revised from a phenyl substituted phenalenone to a hydroxyl substituted phenalenone as a result of its re-purification via HPLC with subsequent NMR analysis together with an independent synthesis and analysis of the crystal structure, which was secured via the crystalline sponge method. On-flow High Performance Liquid Chromatography coupled to Nuclear Magnetic Resonance spectroscopy (HPLC-NMR) was employed to confirm the presence of the natural product in the plant extract and to monitor for any possible degradation or conversion of the compound.

• 出版日期2017-2