Antiulcer activity of ethanolic extract of Encholirium spectabile Mart. ex Schult & Schult f. (Bromeliaceae) in rodents

作者：Moraes de Carvalho Katharinne I; Fernandes Helio B; Frota Machado Flavia D; Oliveira Irisdalva S; Oliveira Francisco A; Nunes Paulo Humberto M^*; Lima Julianeli T; Silva Almeida Jackson R G; Meneses Oliveira Rita C

来源：Biological Research, 2010, 43(4): 459-465.

• antioxidant
• antiulcer activity
• Encholirium spectabile
• Bromeliaceae

This study evaluated the antiulcer activity of an ethanolic extract of Encholirium spectabile (ES-EtOH) by using different standard experimental models of induced acute gastric ulceration. ES-EtOH (100 mg/kg p.o) protected the gastric mucosa against ulceration that was induced by absolute ethanol (53%), ethanol/HCl (75 %), ibuprofen (52 %) and ischemia/reperfusion (43 %). It also restored catalase activity and non-protein sulfhydryl group concentration in the gastric wall of mice that had been treated with ethanol. The pre-treatment of mice with N-nitro-L-arginine (70 mg/kg i.p.) abolished the protective activity of ES-EtOH, which indicates that prostaglandins, antioxidant compounds and nitric oxide synthase activity are involved in the gastroprotective activity of the extract.

• 出版日期2010