Association of IL-6 Polymorphism-174G/C and Metabolic Syndrome in Hypertensive Patients

作者：Teixeira Andrei Alkmim^*; Redublo Quinto Beata Marie; Dalboni Maria Aparecida; de Oliveira Rodrigues Cassio Jose; Batista Marcelo Costa

来源：Biomed Research International, 2015, 2015: 927589.

DOI：10.1155/2015/927589

Introduction. Visceral obesity, the central core of metabolic syndrome (MetS), is conceived as the pathogenic basis of an increased cardiovascular burden and is related with changes in cytokines. We investigated whether IL-6-174G/C gene polymorphism is associated with MetS prevalence in hypertensive patients.
Method. A population of hypertensive patients was included and stratified by the presence of MetS according to IDF criteria and evaluated by Framingham risk score. The IL-6-174G/C genotyping was performed by polymerase chain reaction and the prevalence of MetS was compared between "C" carrier and "non-C" carrier groups.
Results. From an original sample of 664patients, 612(34.2% men, age57.3 +/- 10.1, 30.4% diabetics) were included. MetS was diagnosed in 51.3% of total population and "C" carriers demonstrated high prevalence of MetS (p < 0.05) and each of its components. On binary logistic regression, it was observed that the IL-6 polymorphism was independently associated with occurrence of MetS, even after adjusting for covariates (OR1.13-2.37, 95% CI,p < 0.05).
Conclusion. The Callele at the -174 locus of IL-6 gene is independently associated with the occurrence of metabolic syndrome, emphasizing the importance of inflammatory genetic background in the pathogenesis of visceral obesity and related cardiovascular burden.

• 出版日期2015