Acute cardiovascular responses in preterm infants at 34-39 weeks of gestational age

作者：Viskari Lahdeoja Suvi^*; Hytinantti Timo; Andersson Sture; Kirjavainen Turkka

来源：Early Human Development, 2012, 88(11): 871-877.

DOI：10.1016/j.earlhumdev.2012.07.005

• Baroreflex
• Blood pressure
• Heart rate
• Prematurity
• Vestibular function tests

Background: Premature infants demonstrate immature physiological control mechanisms: however their acute cardiovascular control has not yet been widely studied. %26lt;br%26gt;Aim: The aim of this study was to analyze heart rate (HR) and blood pressure (BP) control in preterm infants. %26lt;br%26gt;Subjects: Twenty preterm infants with a mean gestational age of 31 +/- 2.4 (26-34) weeks at birth were evaluated at a gestational age of 36 +/- 1.5 (34-39) weeks. Results were compared to twenty, healthy, full-term, control infants studied at the age of 12 +/- 3 weeks. %26lt;br%26gt;Outcome measures: HR and BP responses to 45 head-up tilt and side motion tests during non-rapid eye movement sleep were analyzed. In addition, HR responses to spontaneous arousals from non-rapid eye movement sleep were evaluated. %26lt;br%26gt;Results: Preterm infants showed significantly smaller initial HR and BP responses compared with controls in head-up tilt (HR p = 0.0005, systolic BP p = 0.02, diastolic BP p = 0.01) and side motion tests (HR p = 0.002, systolic BP p%26lt;0.0001, diastolic BP p%26lt;0.0001). Furthermore, in tilt tests, preterm infants presented with greater intersubject variability in BP responses than controls (systolic BP p = 0.009, diastolic BP p = 0005). Preterm HR responses to spontaneous arousals were similar to controls. %26lt;br%26gt;Conclusions: This study indicates immature vestibulo-mediated cardiovascular control in preterm infants compared with term infants. This is seen as attenuated BP responses to side motion test and more labile acute BP control to postural challenge.

• 出版日期2012-11