A green and simple synthesis of N-substituted-2-mercaptobenzimidazoles

作者：Rao S Srinivas^*; Dubey P K; Kumari Y Bharathi

来源：Indian Journal of Chemistry - Section B: Organic and Medicinal Chemistry , 2013, 52(9): 1210-1213.

• Green synthesis
• grinding
• microwave
• N-alkyl-2-chlorobenzimidazole
• benzimidazole
• N-alkyl-2-mercaptobenzimidazole

A green and simple synthesis of N-alkyl-2-mercaptobenzimidazoles 5 (R= CH3, C2H5, CH2Ph) under, different conditions has been developed from N-alkyl-2-chlorobenzimidazole (i.e. CH3, C2H5, CH2Ph) 4 by reaction with thiourea by physical grinding or by using green solvents like ethanol, PEG-600, etc. or by using micro-wave irradiation technique.

• 出版日期2013-9