ASSESSMENT OF VECTOR CONTROL AND PHARMACEUTICAL TREATMENT IN REDUCING MALARIA BURDEN: A SENSITIVITY AND OPTIMAL CONTROL ANALYSIS

作者：Sang Zi; Qiu Zhipeng^*; Kong Qingkai; Zou Yun

来源：Journal of Biological Systems, 2012, 20(1): 67-85.

DOI：10.1142/S0218339011500331

• Sensitivity Analysis
• Optimal Control Analysis
• Malaria
• Vector Control Interventions
• Pharmaceutical Treatments

Vector control and pharmaceutical treatments are currently the main methods of malaria control. To assess their impacts on disease transmission and prevalence, sensitivity and optimal control analysis are performed respectively on a mathematical malaria model. Comparisons are made between the result of sensitivity analysis and that of optimal control analysis. Numerical simulation shows that optimal control strategy is available and cost-efficient. The simulating results also indicates that vector control is always much more beneficial than other anti-malaria measures in an optimal control programme. This further suggests that the results of sensitivity analysis by calculating sensitivity indices cannot help policy-makers to formulate a more effective optimal control programme.

• 出版日期2012-3
• 单位南京理工大学