Anti-inflammatory Effects of Compounds from Polygonum odoratum

作者：Okonogi Siri****; Kheawfu Kanta****; Holzer Wolfgang; Unger Frank M; Viernstein Helmut; Mueller Monika^*

来源：Natural Product Communications, 2016, 11(11): 1651-1654.

DOI：10.1177/1934578x1601101107

• Polygonum odoratum
• Inflammation
• Cytokines
• Macrophages
• Quercitrin
• Scutellarein-7-glucoside

Polygonum odoratum is an edible plant traditionally used as an antidiabetic, antimicrobial, anti-inflammatory, and antitumor agent in Asia. The aim of the study was to evaluate the anti-inflammatory effect of P. odoratum and the isolation and characterization of its main fractions. Extracts of the aerial parts were tested for anti-inflammatory activity as indicated by a change in the cytoldne secretion in lipopolysaccharide-stimulated macrophages. After separation of the extract by reversed-phase high-performance liquid chromatography, the anti-inflammatory activity of the fractions was determined. Furthermore, the two main fractions were identified by nuclear magnetic resonance spectroscopy (H-1- and C-13-NMR). The ethanolic extract significantly reduced IL-6 secretion (IC50 25 mu g/mL). The two main fractions (5 and 7) significantly decreased IL-6 production with an IC50 of 102 mu M (5) and 77 mu M (7), respectively, and were identified as scutellarein-7-glucoside (5) and quercitrin (7). Since inflammation plays a major role in various diseases with high prevalence globally, it may be of importance that P. odoratum and its main constituents scutellarein-7-glucoside and quercitrin can be used as either an alternative or complementary treatment. Additionally, both are glycosides and their activity may be enhanced tremendously by deglycosylation by the gut microbiota.

• 出版日期2016-11